SKU: 86450989553

Progressive Retinaatrophie (PRA-BBS4)

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Description

Progressive Retinaatrophie (PRA-BBS4)Die progressive Netzhautatrophie ist die hufigste Ursache fr erbliche Blindheit bei Hunden. Das Bardet Biedl Syndrom 4 (PRA BBS4) ist eine vererbte rezessive Ziliopathie, die bei Puli beschrieben wurde. BBS4 ist eines von acht evolutionren Proteinen, die fr die Zilien auf mehreren Zelltypen essentiell sind. Die Symptome der Erkrankung manifestieren sich aufgrund von Strungen im Wachstumserhalt und oder in der Funktion der Zilien. Die progressive

Die progressive Netzhautatrophie ist die häufigste Ursache für erbliche Blindheit bei Hunden. Das Bardet-Biedl-Syndrom 4 (PRA-BBS4) ist eine vererbte rezessive Ziliopathie, die bei Puli beschrieben wurde. BBS4 ist eines von acht evolutionären Proteinen, die für die Zilien auf mehreren Zelltypen essentiell sind. Die Symptome der Erkrankung manifestieren sich aufgrund von Störungen im Wachstumserhalt und/oder in der Funktion der Zilien. Die progressive Netzhautatrophie (PRA-BBS4) ist durch einen allmählichen Verlust des Sehvermögens gekennzeichnet, aufgrund der Degeneration von Photorezeptorzellen in der Netzhaut. Die Degeneration schreitet fort, bis die betroffenen Hunde vollständig blind sind. Weitere Symptome, wenn die Netzhaut sich verschlechtert, sind tapetale Hyperreflexion, vaskuläre Abschwächung, pigmentäre Veränderungen und Atrophie des Sehnervenkopfes.

Vererbung: autosomal rezessiv

Mutation: BBS4-Gen

Gentest: Die verwendete Methode für genetische Tests ist äußerst genau und ermöglicht eine vollständige Unterscheidung zwischen betroffenen Tieren, Trägern und gesunden Hunden. DNA-Tests können in jedem Alter durchgeführt werden.

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SKU: 86450989553

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4.7 ★★★★★
Based on 29 reviews
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Verified Purchase
Bgsikes
Los Angeles, US
★★★★★ 5
great
Format: Hardcover
great
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 10, 2026
R
Rebecca Hill
Waukegan, US
★★★★★ 4
Chilling History
Format: Hardcover
The police action in Korea began to heat up very quickly, as Chinese troops began to pour over the border, and take up defensive positions. The Marines that were deployed to the area had their hands full, trying to keep even more troops from crossing, while also defending the surrounding area. The horrific weather conditions, without the proper gear, and the determination of the Marines to refuse to give ground gave way to a very volatile situation. With temperatures continuing to plumate, the biggest enemy on either side was not munitions, it was frostbite and death. Many soldiers froze to death. Chinese soldiers were issued cold weather gear that was far below what was needed for the sub-zero temperatures of the region. Soldiers from the United States were not initially given the correct gear, although there was a push to get what was needed, but many still lost fingers and toes to frostbite. Medical units were also not fully prepared for the onslaught that was coming their way. Many found themselves overwhelmed with wounded, while low on supplies and materials. This was a great read, and a real eye-opener on the deprivations that were suffered by both sides during the beginning of the Korean War. Joseph Wheelan again brings a great amount of detail, both tactical and strategic, as we look at one of the more brutal aspects of the Korean War.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 26, 2026
A
Verified Purchase
Arrow55
Louisville, US
★★★★★ 5
Very good author.
Format: Hardcover
Chosin Reservoir is what everyone who knows someone involved in the Korean Conflict will want to read about. Wheelan is an outstanding writer, able to help you visualize the horror our military experienced. The author reveals some of the human blind spots in decision making by commanders leading to the tragedy.
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Reviewed in the United States on January 2, 2026
M
Verified Purchase
Michael H
Lowell, US
★★★★★ 5
Why wasn’t MacArthur court martialed?
Format: Hardcover
If there is a better book about overcoming the impossible, please send the title. Leadership at every level except the very top as well as the esprit de corps of USMC carried the day against overwhelming numbers of Chinese armies ( yes, armies - hundreds of thousand against USA and USMC troops). The Korean War doesn’t get the respect it deserves. Emperor MacArthur sat on his butt in Tokyo refusing to believe he could be wrong while Chinese armies crossed the Yalu intent on destroying the 1st MARDIV and the USA units east of the Chosin Reservoir. He spent one night in Korea during the entire war until President Truman fired his ass and rightly so.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 22, 2025
J
Verified Purchase
John G
Bozeman, US
★★★★★ 5
Comprehensive analysis of the Chosin Reservoir campaign
Format: Hardcover
Excellent excellent review and analysis of the Chosin Resevoir campaign. The author examines the battle day-by-day from the Marines, Army, and Chinese Army perspective. This should be a required reference when studying the battle to understand lessons learned. So often books on this campaign are fragmented. In this book, he put the exciting descriptions of the action in the context of the broader campaign. I really appreciated how he included Task Force McLean/Faith which often gets omitted. After reading a number of books on this battle, I knew what was going to happen, but have to admit that it was hard to put this book down. HIGHLY highly recommended.
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Reviewed in the United States on March 15, 2025

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